ML 311

Key Product Details

Product Description

ML 311 is an inhibits Mcl1-BIM interaction. Inhibits viability of Mcl1-dependent tumor cell lines. Induces cell death and decreased spheroid formation in Her2 positive breast cancer cells.

Product Specifications for ML 311

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 311

The following data is based on the product molecular weight 415.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.81 mL	24.07 mL	48.14 mL
2.5 mM	0.96 mL	4.81 mL	9.63 mL
5 mM	0.48 mL	2.41 mL	4.81 mL
25 mM	0.10 mL	0.48 mL	0.96 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Bannister ML311: A small molecule that potently and selectively disrupts the protein-protein interaction of Mcl-1 and Bim: a probe for studying lymphoid tumorigenesis. Probe Reports from the NIH Molecular Libraries Program 2012 PMID: 23762927
• Bashari Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications. Breast Cancer Res. 2016 PMID: 26921175

Product Documents for ML 311