ML 323

Key Product Details

Product Description

ML 323 is a potent and selective allosteric inhibitor of USP1-UAF1 deubiquitinase complex (IC₅₀ = 76 nM). Exhibits selectivity for USP1-UAF1 over a panel of enzymes, including other deuquitinating enzymes. Inhibits deubiquitination of PCNA and FANCD2 and sensitizes cisplatin-resistant H596 cells to cell death induced by cisplatin (Cat. No. 2251) in vitro.

Product Specifications for ML 323

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 323

The following data is based on the product molecular weight 384.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.60 mL	13.00 mL	26.01 mL
5 mM	0.52 mL	2.60 mL	5.20 mL
10 mM	0.26 mL	1.30 mL	2.60 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Liang A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat.Chem.Biol. 2014 PMID: 24531842

Product Documents for ML 323