ML 348

Key Product Details

Product Description

ML 348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC₅₀ = 210 nM). Exhibits 14-fold selectivity for LYPLA1 over LYPLA2. Also selective over a panel of ~30 other serine hydrolases.

Product Specifications for ML 348

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 348

The following data is based on the product molecular weight 415.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.03 mL	24.05 mL
5 mM	0.48 mL	2.41 mL	4.81 mL
10 mM	0.24 mL	1.20 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

• Hernandez APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells. Cell Chem.Bio. 2017 PMID: 28065656
• Adibekian Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program 2013 PMID: 24624465

Product Documents for ML 348