ML SA1

Key Product Details

Product Description

ML SA1 is an activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca²⁺ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages. Activation of TRPML1 by ML SA1 causes membrane accumulation of aquaporin-3 and -5, and significant depolymerization of the actin cytoskeleton, in human lymphatic endothelial cells (HLECs).

Product Specifications for ML SA1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML SA1

The following data is based on the product molecular weight 362.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.80 mL	68.98 mL	137.96 mL
1 mM	2.76 mL	13.80 mL	27.59 mL
2 mM	1.38 mL	6.90 mL	13.80 mL
10 mM	0.28 mL	1.38 mL	2.76 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 36 publications citing the usage of this product.

• Weiss Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases. Commun.Integr.Biol. 2012 PMID: 22808310
• Yang TRPML1 acts as a predisposing factor in lymphedema development by regulating the subcellular localization of aquaporin-3, -5. PLoS One 2024 PMID: 39637010
• Shen Lipid storage disorders block lysosomal trafficking by inhibiting TRP channel and calcium release. Nat.Commun. 2012 PMID: 22415822

Product Documents for ML SA1