MLi-2

Tocris Bioscience | Catalog # 5756

Potent and selective LRRK2 inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective LRRK2 inhibitor
View all LRRK2 Inhibitors »

Product Description

MLi-2 is a potent and selective LRRK2 inhibitor (IC50 = 0.76-3.4 nM depending on assay), which exhibits >295-fold selectivity for over 300 kinases and a diverse panel of receptors and ion channels. MLi-2 is centrally bioavailable and active in vivo.

External Portal Information

Chemicalprobes.org

and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of MLi-2 is reviewed on chemicalprobes.org and the SGC website.

Product Specifications for MLi-2

Molecular Weight

379.46

Formula

C21H25N5O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

rel-3-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-pyrimidyl]-5-[(1-methylcyclopropyl)oxy]-1H-indazole

CAS Number

1627091-47-7

PubChem ID

78319901

InChI Key

ATUUNJCZCOMUKD-OKILXGFUSA-N

SMILES

CC1(CC1)OC2=CC=C3C(C(C4=NC=NC(N5C[C@@H](C)O[C@@H](C)C5)=C4)=NN3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.97 50

Preparing Stock Solutions for MLi-2

The following data is based on the product molecular weight 379.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.27 mL 26.35 mL 52.71 mL
2.5 mM 1.05 mL 5.27 mL 10.54 mL
5 mM 0.53 mL 2.64 mL 5.27 mL
25 mM 0.11 mL 0.53 mL 1.05 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 76 publications citing the usage of this product.

Product Documents for MLi-2

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MLi-2

For research use only

Customer Reviews for MLi-2 (1)

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  • Good LRRK2 inhibitor
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Primary hippocampal neurons
    Verified Customer | Posted 01/27/2023
    The drug was incubated at 500 nM to inhibit LRRK2.

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