MLN 4760

Key Product Details

Product Description

MLN 4760 is a highly potent, cell-permeable and selective inhibitor of angiotensin converting enzyme 2 (ACE2) (IC₅₀ = 0.44 nM). MLN 4760 inhibits production of angiotensin (1-7) from angiotensin II and reduces ACE2 expression and activity in an animal model of lung inflammation.

Product Specifications for MLN 4760

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MLN 4760

The following data is based on the product molecular weight 428.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.67 mL	23.35 mL
5 mM	0.47 mL	2.33 mL	4.67 mL
10 mM	0.23 mL	1.17 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Sodhi A dynamic variation of pulmonary ACE2 is required to modulate neutrophilic inflammation in response to Pseudomonas aeruginosa lung infection in mice. J.Immunol. 2019 PMID: 31645418
• Mores Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2. J.Med.Chem. 2008 PMID: 18324760

Product Documents for MLN 4760