Modafinil

Key Product Details

Product Description

Modafinil is a psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Modafinil promotes vigilance and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.

Product Specifications for Modafinil

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Modafinil

The following data is based on the product molecular weight 273.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	4.88 mL	24.39 mL	48.78 mL
3.75 mM	0.98 mL	4.88 mL	9.76 mL
7.5 mM	0.49 mL	2.44 mL	4.88 mL
37.5 mM	0.10 mL	0.49 mL	0.98 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Jenner Antiparkinsonian and neuroprotective effects of moda. in the mtpt-treated common marmoset. Exp.Brain Res. 2000 PMID: 10968218
• Madras Modafinil occupies DA and NE transporters in vivo and modulates the transporters and trace amine activity in vitro. J.Pharmacol.Exp.Ther. 2006 PMID: 16885432
• Ferraro Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and DA uptake blockers. Biol.Psychiatry 1997 PMID: 9426889

Product Documents for Modafinil