Mouse Afamin Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Afamin

Afamin, also known as AFM or alpha -Albumin, is an 84-88 kDa secreted monomeric glycoprotein member of the Alb/albumin family of molecules. Expressed by hepatocytes, CNS endothelial cells and osteoclasts, Afamin circulates in the blood at low μg/mL concentrations. Afamin is known to bind and transport vitamin E, particularly under conditions where lipoprotein is limited. This is likely to be important in follicular fluid and CSF. Afamin also serves as an osteoclast-derived chemoattractant for preosteoblasts, providing a rationale for the observation that bone formation often follows bone resorption. Mature mouse Afamin is 587 amino acids (aa) in length (aa 22-608). It contains three consecutive albumin domains (aa 22-210, 211-403 and 404-599) that contain characteristic 5 or 6 intrachain disulfide bonds. Full-length mouse Afamin shares 67% aa sequence identity with human Afamin.

Product Datasheets

Related Research Areas

• Cancer Biomarkers