Mouse APLP-2 Antibody

Catalog #: AF3685
1 Citation Datasheet / COA / SDS

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AF3685
AF3685-SP

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All APLP-2 Antibodies

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Citations (1)

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse APLP-2 Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse APLP-2 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant human (rh) APLP-2 is observed and less than 1% cross-reactivity with rhAPLP-1 and recombinant mouse APLP-1 is observed.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse APLP-2
Leu37-Ser624
Accession # AAH52396.2

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Mouse APLP‑2

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: APLP-2

Mouse APLP-2 is a 120-170 kDa (695 aa) member of the APP family of type I transmembrane (TM) proteins. Its 595 aa extracellular region has multiple domains, including an N-terminal Cys-rich domain, an Asp/Glu-rich acidic region, and a membrane proximal linker region that contains a GAG attachment site. Several alternatively spliced APLP-2 isoforms have been reported. APLP-2 is proteolytically cleaved by MMPs and secretases and forms both homodimers and heterodimers with APP and APLP-1. Over the range used as immunogen, mouse APLP-2 shares 97% and 91% aa sequence identity with rat and human ALPL-2, respectively.

Long Name

Amyloid Beta [A4] Precursor-like Protein 2

Entrez Gene IDs

334 (Human); 11804 (Mouse); 64312 (Rat)

Alternate Names

amyloid beta (A4) precursor-like protein 2; amyloid precursor protein homolog HSD-2; Amyloid protein homolog; amyloid-like protein 2; APLP2; APLP-2; APPH; APPHCDEI box-binding protein; APPL2; CDEBP; WALPLP2; YWK-II

Product Datasheets

Product Datasheet

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Related Research Areas

Citation for Mouse APLP-2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1