Mouse BTN2A2/Butyrophilin 2A2 Alexa Fluor® 594-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: BTN2A2/Butyrophilin 2A2

Mouse Butyrophilin 2 (BTN2; also Btn2a2) is a 65‑70 kDa member of the BTN/MOG family of proteins. It is expressed on colonic epithelium and endothelial cells, and marginally on monocytes. The counterreceptor for BTN2 is DC-SIGN and binding is predicated on the presence of BTN2 mannose residues. Mature mouse BTN2 is presumably 487 amino acids (aa) in length. It is a type I transmembrane glycoprotein that potentially contains a 206 aa extracellular domain (ECD) (aa 29‑234). The ECD contains one V-type (aa 52‑129) and one C2-type (aa 152‑234) Ig-like domain. There is one alternative splice variant. It shows a deletion of aa 372‑400 plus a 17 aa substitution for aa 422‑451. Over aa 30‑248, mouse BTN2 shares 70% and 89% aa identity with human and rat BTN2, respectively.

Product Datasheets

Related Research Areas

• Butyrophilins
• Co-stimulatory and Co-inhibitory Molecules
• Search Immune Checkpoint Targets