Mouse G2A/GPR132 (NP_064309) VersaClone cDNA

Name: Mouse G2A/GPR132 (NP_064309) VersaClone cDNA
Brand: R&D Systems
SKU: RDC0882
Price: 270 USD
Availability: InStock

R&D Systems | Catalog # RDC0882

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Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species

Mouse

Accession Number

NP_064309

Background: G2A/GPR132

GPR132, also known as G2A (for G2 accumulation), is a seven transmembrane G protein-coupled receptor that is upregulated in response to DNA damage and stress. G2A is predominantly expressed in hematopoietic tissues and in hematopoietic stem cells, and it is more highly detected in pro-B cells, while lower expression is observed in immature B cells and pre-B cells. G2A is expressed throughout T cell maturation, and it is further increased in response to T-cell activation. Ectopic expression of a G2A fusion protein in NIH/3T3 fibroblasts induces a cell cycle arrest that is consistent with a block at the G2/M transition. G2A is also able to attenuate the proliferative effects of Bcr-Abl, a chimeric tyrosine kinase oncogene, suggesting that G2A possesses anti-oncogenic properties. The amino acid sequence of G2A contains a destruction box motif that is consistently observed in cyclins, where it is required for ubiquitination and proteolytic degradation.

Long Name

G2 Accumulation Protein

Alternate Names

GPR132

Entrez Gene IDs

29933 (Human); 56696 (Mouse); 314480 (Rat)

Gene Symbol

GPR132

UniProt

NP_064309

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Product Specific Notices for Mouse G2A/GPR132 (NP_064309) VersaClone cDNA

For research use only

Related Research Areas

Bioactive Lipids and Receptors

Obesity

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