Mouse Prostasin/Prss8 Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Prostasin/Prss8

Prostasin encoded by the Prss8 gene, also known as channel activating protease 1, is a serine protease with a trypsin-like substrate specificity (1, 2). The preproenzyme possesses a C-terminal membrane-spanning domain that can be proteolytically processed to generate a secreted form of the enzyme. The secreted form of prostasin has been purified from seminal fluid (2). Prostasin is highly expressed in the prostate gland, and is expressed at lower levels in the lung, kidney, liver, salivary gland, and pancreas (3). The peptidase activity of prostasin is involved in the regulation of epithelial sodium channels (4, 5). The enzymatic activity of Prostasin is effectively inhibited by HAI-1 and HAI-2B (Catalog # 1141-PI and 1107-PI).

Product Datasheets

Related Research Areas

• Epithelial Cell Markers and Intracellular Molecules
• Search Bioprocessing Enzymes
• Serine Proteases and Regulators
• Surface Ectodermal Cells