Mouse SUCNR1/GPR91 (NP_115776) VersaClone cDNA

Name: Mouse SUCNR1/GPR91 (NP_115776) VersaClone cDNA
Brand: R&D Systems
SKU: RDC0726
Price: 270 USD
Availability: InStock

R&D Systems | Catalog # RDC0726

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Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species

Mouse

Accession Number

NP_115776

Background: SUCNR1/GPR91

GPR91 (formerly known as P2U2) is a G protein-coupled, dicarboxylic acid succinate receptor. It has a high level of expression in the kidney, predominantly in the proximal tubules, and localizes to the plasma membrane. It has also been found at low levels in the liver and the spleen. GPR91 functions as a citric acid cycle intermediate succinate receptor. Two signaling pathways result from GPR91 activation, the pertussis-toxin-sensitive Gi/Go pathway and the pertussis-toxin-insensitive Gq pathway. Four amino acid residues are necessary for GPR91 activation by succinate: Arg 99, His 103, Arg 252 and Arg 281. GPR91 plays an important role in the succinate-induced hypertensive effect and may be involved in renovascular hypertension, a disease linked to diabetes, renal failure and atherosclerosis.

Long Name

Succinate Receptor 1

Alternate Names

GPR91

Entrez Gene IDs

56670 (Human); 84112 (Mouse); 408199 (Rat)

Gene Symbol

SUCNR1

UniProt

NP_115776

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Product Specific Notices for Mouse SUCNR1/GPR91 (NP_115776) VersaClone cDNA

For research use only

Related Research Areas

Obesity

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