MRS 1706

Key Product Details

Product Description

MRS 1706 is a potent and selective adenosine A_2B receptor inverse agonist (K_i values are 1.39, 157, 112 and 230 nM for human A_2B, A₁, A_2A and A₃ receptors respectively).

Licensing Information

Manufactured and sold under license from Adenosine Therapeutics, LLC

Product Specifications for MRS 1706

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MRS 1706

The following data is based on the product molecular weight 503.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	39.72 mL	198.59 mL	397.17 mL
0.25 mM	7.94 mL	39.72 mL	79.43 mL
0.5 mM	3.97 mL	19.86 mL	39.72 mL
2.5 mM	0.79 mL	3.97 mL	7.94 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

• Li ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A_2B receptor. J.Pharmacol.Exp.Ther. 2007 PMID: 17077318
• Kiec-Kononowicz New developments in A₁ and A₂ adenosine receptor antagonists. Pure Appl.Chem.
• Kim Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A_2B adenosine receptors. J.Med.Chem. 2000 PMID: 10737749

Product Documents for MRS 1706