MRS 2578

Tocris Bioscience | Catalog # 2146

Selective P2Y6 antagonist
Tocris Bioscience

Key Product Details

Description

Selective P2Y6 antagonist
View all P2Y Receptor Antagonists »

Product Description

MRS 2578 is a selective antagonist of P2Y6 nucleotide receptors; IC50 values are 37 and 98 nM at human and rat P2Y6 receptors respectively. Displays no activity at P2Y1, P2Y2, P2Y4 and P2Y11 receptors (IC50 > 10 μM). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis.

Product Specifications for MRS 2578

Molecular Weight

472.66

Formula

C20H20N6S4

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

N,N''-1,4-Butanediylbis[N'-(3-isothiocyanatophenyl)thiourea

CAS Number

711019-86-2

PubChem ID

16078986

InChI Key

QOHNRGHTJPFMSL-UHFFFAOYSA-N

SMILES

S=C(NCCCCNC(NC2=CC(N=C=S)=CC=C2)=S)NC1=CC(N=C=S)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.63 50

Preparing Stock Solutions for MRS 2578

The following data is based on the product molecular weight 472.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.23 mL 21.16 mL 42.31 mL
2.5 mM 0.85 mL 4.23 mL 8.46 mL
5 mM 0.42 mL 2.12 mL 4.23 mL
25 mM 0.08 mL 0.42 mL 0.85 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 76 publications citing the usage of this product.

Product Documents for MRS 2578

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MRS 2578

For research use only

Related Research Areas

Bioactive Lipids and Receptors

Customer Reviews for MRS 2578 (2)

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  • Good inhibitor
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: phagocyte
    Verified Customer | Posted 06/06/2020
    DMSO dilution 10 μM
    MRS 2578 2146
  • MRS 2578 inhibits LPS-induced inflammation
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Macrophages
    Verified Customer | Posted 01/22/2019
    RAW macrophages were stimulated with LPS (200 ng/ml) in the absence or presence of A 804598 (1 μM) or MRS 2578 (100 μM) for 8 h to follow iNOS expression by qPCR. Both compounds inhibited LPS-induced iNOS expression revealing role of purinergic receptors.
    MRS 2578 2146

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