MRS 5698

Key Product Details

Product Description

MRS 5698 is a high affinity and selective A₃ adenosine receptor agonist (K_i ~ 3 nM); displays >1000-fold selectivity over A₁ and A_2A adenosine receptors. Reverses mechanoallodynia in several neuropathic pain models in vivo. Orally bioavailable.

Product Specifications for MRS 5698

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MRS 5698

The following data is based on the product molecular weight 564.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.70 mL	88.50 mL	177.00 mL
0.5 mM	3.54 mL	17.70 mL	35.40 mL
1 mM	1.77 mL	8.85 mL	17.70 mL
5 mM	0.35 mL	1.77 mL	3.54 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Tosh Structure-guided design of A₃ adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions. J.Med.Chem. 2012 PMID: 22559880
• Tosh Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A₃ adenosine receptor agonist that protects against chronic neuropathic pain. Purinergic Signal. 2015 PMID: 26111639
• Little Endogenous adenosine A₃ receptor activation selectively alleviates persistent pain states. Brain 2015 PMID: 25414036

Product Documents for MRS 5698