MS 143

Key Product Details

Product Description

MS 143 is a potent and selective protein kinase B (AKT) Degrader (PROTAC^®) (DC₅₀ = 46 nM, D_max = 100 % at 24h in PC3 cells). MS 143 suppresses growth in prostate cancer PC3 cells; suppresses tumor growth and reduces AKT protein levels in a mouse PC3 cell xenograft model.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Icahn School of Medicine at Mount Sinai.

Product Specifications for MS 143

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MS 143

The following data is based on the product molecular weight 1121.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.89 mL	4.46 mL	8.91 mL
5 mM	0.18 mL	0.89 mL	1.78 mL
10 mM	0.09 mL	0.45 mL	0.89 mL
50 mM	0.02 mL	0.09 mL	0.18 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Yu Discovery of potent, selective, and in vivo efficacious AKT kinase protein degraders via structure-activity relationship studies. J.Med.Chem. 2022 PMID: 35119851

Product Documents for MS 143