MS 21570

Key Product Details

Product Description

MS 21570 is a GPR171 antagonist (IC₅₀ = 220 nM). Inhibits BigLEN (Cat.No. 6304) mediated increases in [³⁵S]GTPγS binding in hypothalamic membranes and hyperpolarization of basolateral amygdala pyramidal neurons. Reduces anxiety-like behavior and fear conditioning in mice.

Product Specifications for MS 21570

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MS 21570

The following data is based on the product molecular weight 237.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.21 mL	21.07 mL	42.13 mL
5 mM	0.84 mL	4.21 mL	8.43 mL
10 mM	0.42 mL	2.11 mL	4.21 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Bobeck The BigLEN-GPR171 peptide receptor system within the basolateral amygdala regulates anxiety-like behavior and contextual fear conditioning. Neuropsychopharmacology 2017 PMID: 28425495

Product Documents for MS 21570