MS 41

Tocris Bioscience | Catalog # 8919

Potent and selective ENL Degrader (PROTAC®)
Tocris Bioscience
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Key Product Details

Description

Potent and selective ENL Degrader (PROTAC®)
View all PROTACs (Proteolysis Targeting Chimeras) »

Product Description

MS 41 is a potent and selective Eleven-Nineteen Leukemia (ENL) Degrader (PROTAC®) (DC50 = 2.84 nM, 3.03 nM, 3.50 nM and 26.58 nM in SEMK2, Jurkat, MV4;11 and KASUMI1 cells, respectively). Comprises an ENL-binding moiety (PFI-6) joined by a linker to VHL1-Me as the ligand for von Hippel-Lindau E3 ubiquitin ligase. MS41 effectively inhibits leukemia cell proliferation and clonogenic ability in vitro and suppresses leukemia progression in a xenograft mouse model of MLL-r leukemia in vivo.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license

Product Specifications for MS 41

Molecular Weight

1031.28

Formula

C56H70N8O9S

Storage

Store at -20°C

Purity

≥97%

Chemical Name

5-[4-(Dimethylcarbamoyl)-3-hydroxyphenyl]-N-[(1R)-6-[[10-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-10-oxodecyl]carbamoyl]-2,3-dihydro-1H-inden-1-yl]-1,2-oxazole-3-carboxamide

CAS Number

2768610-97-3

PubChem ID

172407974

InChI Key

XPICNVKPGAOVBF-VCNVHFLLSA-N

SMILES

O=C(N[C@H]1C2=CC(C(NCCCCCCCCCC(N[C@H](C(N3[C@H](C(N[C@@H](C)C4=CC=C(C=C4)C5=C(C)N=CS5)=O)C[C@@H](O)C3)=O)C(C)(C)C)=O)=O)=CC=C2CC1)C6=NOC(C7=CC(O)=C(C(N(C)C)=O)C=C7)=C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 103.13 100

Preparing Stock Solutions for MS 41

The following data is based on the product molecular weight 1031.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.97 mL 4.85 mL 9.70 mL
5 mM 0.19 mL 0.97 mL 1.94 mL
10 mM 0.10 mL 0.48 mL 0.97 mL
50 mM 0.02 mL 0.10 mL 0.19 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

  • Xue A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression. Sci.Adv.

Product Documents for MS 41

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MS 41

For research use only

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