MS 4322

Tocris Bioscience | Catalog # 8080

Selective PRMT5 Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Selective PRMT5 Degrader (PROTAC®)
View all Active Degraders »

Product Description

MS 4322 is a protein arginine methyltransferase 5 (PRMT5) Degrader (PROTAC®) (DC50 = 1.1 μM, Dmax = 74% in MCF-7 cells). Also inhibits PRMT5 methyltransferase activity (IC50 = 18 nM) and dose-dependently inhibits proliferation of HeLa, A549, A172 and Jurkat cancer cell lines. Comprises a PRMT5 inhibitor linked to an E3 ligase ligand.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for MS 4322

Molecular Weight

1101.33

Formula

C55H76N10O12S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-((S)-3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-((1-((S)-19-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-20,20-dimethyl-17-oxo-3,6,9,12,15-pentaoxa-18-azahenicosanoyl)azetidin-3-yl)amino)pyrimidine-4-carboxamide

CAS Number

2375432-47-4

PubChem ID

162652211

InChI Key

XUJMNOQMXWVXQE-STHBVIMFSA-N

SMILES

O=C(N1CC(C1)NC2=NC=NC(C(NC[C@H](O)CN3CC4=CC=CC=C4CC3)=O)=C2)COCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 110.13 100

Preparing Stock Solutions for MS 4322

The following data is based on the product molecular weight 1101.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.91 mL 4.54 mL 9.08 mL
5 mM 0.18 mL 0.91 mL 1.82 mL
10 mM 0.09 mL 0.45 mL 0.91 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for MS 4322

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MS 4322

For research use only

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