MTK 458

Key Product Details

Product Description

MTK 458 is a brain penetrant PTEN-induced kinase 1 (PINK1) activator. It binds to and stabilizes the active form of PINK1, increasing its activity and activating mitophagy downstream. It mediates clearance of pathogenic α-synuclein and normalizes pS65-Ubiquitin (pUb) in in vivo Parkinson's models. MTK458 is orally bioavailable.

Licensing Information

Sold with kind permission of Mitokinin

Product Specifications for MTK 458

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MTK 458

The following data is based on the product molecular weight 332.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.02 mL	30.09 mL	60.18 mL
2.5 mM	1.20 mL	6.02 mL	12.04 mL
5 mM	0.60 mL	3.01 mL	6.02 mL
25 mM	0.12 mL	0.60 mL	1.20 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Chin Pharmacological PINK1 activation ameliorates pathology in Parkinson's disease models. bioRxiv 2023 PMID: 36824886

Product Documents for MTK 458