Muristerone A

Name: Muristerone A
Brand: Tocris Bioscience
SKU: 3816

Tocris Bioscience | Catalog # 3816

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Product Documents

Stimulates Bcl-XL mRNA transcription; antiapoptotic

Discontinued Product

3816 has been discontinued. View all Additional Bcl-2 Family Compounds products.

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Product Description
Product Specifications
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Background References
Product Documents
Specific Notices
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Key Product Details

Description

Stimulates Bcl-XL mRNA transcription; antiapoptotic

View all Additional Bcl-2 Family Compounds »

Product Description

Muristerone A is an ecdysone analog that acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells.

Product Specifications for Muristerone A

Molecular Weight

496.63

Formula

C₂₇H₄₄O₈

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

(2β,3β,5β,11α,22R)-2,3,5,11,14,20,22-Heptahydroxycholest-7-en-6-one

CAS Number

38778-30-2

PubChem ID

122217

InChI Key

LRJUYAVTHIEHAI-LHBNDURVSA-N

SMILES

O[C@@H]1[C@H](O)C[C@](C(C=C3[C@@]([H])2[C@H](O)C[C@@]4(C)[C@](O)3CC[C@@]([H])4[C@](O)(C)[C@H](O)CCC(C)C)=O)(O)[C@]2(C)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

No Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc.Natl.Acad.Sci.USA
Bosser and Zornig Agonists of an ecdysone-inducible mammalian expression system inhibit Fas-ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO. Cell Death Diff.
Patrick Muristerone A-induced nerve growth factor release from genetically engineered human dermal fibroblasts for peripheral nerve tissue engineering. Tissue Eng. 2001 PMID: 11429150

Product Documents for Muristerone A

Certificate of Analysis

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Product Specific Notices for Muristerone A

For research use only

Related Research Areas

Bcl-2 Proteins and Regulators

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