N¹,N¹²-Diethylspermine tetrahydrochloride

Key Product Details

Product Description

N¹,N¹²-Diethylspermine tetrahydrochloride is a powerful antineoplastic agent in cultured cells and animal tumors (IC₅₀ = 0.2 μM in L1210 cells). Inhibitor of polyamine synthases. Suppressor of mitochondrial DNA synthesis.

Product Specifications

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions

The following data is based on the product molecular weight 404.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.37 mL	24.73 mL
5 mM	0.49 mL	2.47 mL	4.95 mL
10 mM	0.25 mL	1.24 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Vertino Selective cellular depletion of mitochondrial DNA by the polyamine analog N¹,N¹²-bis(ethyl)spermine and its relationship to polyamine structure and function. Mol.Pharmacol. 1991 PMID: 2017149
• Bergeron Synthesis and bioloigcal evaluation of aminopolyamines. J.Med.Chem. 2005 PMID: 15857111
• Porter Combined regulation of arginine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N¹,N¹²-bis(ethyl)spermine. Biochem.J. 1990 PMID: 2344358
• Bergeron Synthetic polyamine analogues as antineoplastics. J.Med.Chem. 1988 PMID: 3373487

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