N106

Key Product Details

Product Description

N106 is an activator of SUMO-activating enzyme, E1 ligase. Increases SERCA2a SUMOylation and activity, and enhances contractility in rat cardiomyocytes in vitro. Improves ventricular function in a mouse model of heart disease.

Product Specifications for N106

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for N106

The following data is based on the product molecular weight 354.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.11 mL	70.55 mL	141.09 mL
1 mM	2.82 mL	14.11 mL	28.22 mL
2 mM	1.41 mL	7.05 mL	14.11 mL
10 mM	0.28 mL	1.41 mL	2.82 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Kho Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure. Nat.Commun. 2015 PMID: 26068603

Product Documents for N106