Napabucasin

Key Product Details

Product Description

Napabucasin is a STAT3 inhibitor. Blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells. Inhibits PaCa-2 xenograft tumor growth in mice, even after cessation of treatment, and decreases population of CSCs in PaCa-2 tumors from treated mice. Also blocks spleen and liver metastases of colon cancer cells in a mouse model.

Product Specifications for Napabucasin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Napabucasin

The following data is based on the product molecular weight 240.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	20.82 mL	104.08 mL	208.15 mL
1 mM	4.16 mL	20.82 mL	41.63 mL
2 mM	2.08 mL	10.41 mL	20.82 mL
10 mM	0.42 mL	2.08 mL	4.16 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Li Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc.Natl.Acad.Sci.USA. 2015 PMID: 25605917

Product Documents for Napabucasin