NBC 6

Tocris Bioscience | Catalog # 6925

NLRP3 inflammasome inhibitor
Tocris Bioscience
Discontinued Product
6925 has been discontinued. View all Inflammasomes Inhibitors products.

Key Product Details

Description

NLRP3 inflammasome inhibitor
View all Inflammasomes Inhibitors »

Product Description

NBC 6 is a NLRP3 inflammasome inhibitor (IC50 = 574 nM). Inhibits nigericin-induced inflammasome activation in THP-1 cells and Imiquimod (Cat. No. 3700) induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).

Licensing Information

Sold under license from the University of Manchester.

Product Specifications for NBC 6

Molecular Weight

409.50

Formula

C18H16BCl3N2O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(T4)-[2-Acetyl-4,4,4-trichloro-3-(imino-κN)butanamidito-κO]diphenylboron

CAS Number

2068818-02-8

PubChem ID

145237739

InChI Key

VKECODDKRKQJNM-UHFFFAOYSA-N

SMILES

CC(C1=C(C(Cl)(Cl)Cl)N[B-](C2=CC=CC=C2)(C3=CC=CC=C3)[O+]=C1N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.95 100
Ethanol 2.05 5

Preparing Stock Solutions for NBC 6

The following data is based on the product molecular weight 409.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for NBC 6

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NBC 6

For research use only

Customer Reviews for NBC 6 (1)

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  • NBC 6 can efficiently block pyroptosis induction
    Name: Xiaogang Wang
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: THP-1 cells
    Verified Customer | Posted 06/12/2020
    We ordered this product, combining with another pyroptosis inhibitor NSA, to confirm the induction of pyroptosis by staphylococcal virulence factors. We have shown that NSA significantly inhibited the release of LDH by THP-1 cells treated with staphylococcal products. To confirm that tested staphylococcal product induces pyroptosis, we also used 20 uM NBC 6 to pretreat THP-1 cells before incubating with staphylococcal product. Similarly, treatment of THP-1 cells with NBC 6 also significantly decreased the release of LDH in THP-1 cells treated by staphylococcal product.
    NBC 6 6925

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