NCX 4040

Key Product Details

Product Description

NCX 4040 is a NO-donating aspirin; anti-inflammatory. Blocks inflammatory mediator production in isolated human monocytes (IC₅₀ values are 0.07, 0.13, 0.15 and 0.18 μM for IL-1β, PGE₂, IL-10 and TNF-α respectively). Decreases COX-2 expression (IC₅₀ = 0.13 μM); disrupts proteasome-mediated degradation of iκB-α. Antiproliferative in HCT116 colon cancer cells; sensitizes drug-resistant ovarian tumor cells to cisplatin (Cat. No. 2251).

Product Specifications for NCX 4040

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NCX 4040

The following data is based on the product molecular weight 331.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.02 mL	15.09 mL	30.19 mL
5 mM	0.60 mL	3.02 mL	6.04 mL
10 mM	0.30 mL	1.51 mL	3.02 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Gao Immunomodulatory activity of synthetic triterpenoids: inhibition of lymphocyte proliferation, cell-mediated cytotoxicity, and cytokine gene expression through suppression of NF-κB. Immunopharmacol.Immunotoxicol. 2008 PMID: 18608528
• Yamakawa Growth inhibition of human colon cancer cell line HCT116 by bis[2-(acylamino)phenyl] disulfide and its action mechanism. Biol.Pharm.Bull. 2008 PMID: 18451518
• Bratasz NCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisp. by depletion of cellular thiols. J.Transl.Med. 2008 PMID: 18302761
• Ricciotti NCX 4040, a nitric oxide-donating aspirin, exerts anti-inflammatory effects through inhibition of I kappa B-alpha degradation in human monocytes. J.Immunol. 2010 PMID: 20065114

Product Documents for NCX 4040