NECA

Tocris Bioscience | Catalog # 1691

High affinity adenosine agonist
Tocris Bioscience

Key Product Details

Description

High affinity adenosine agonist

Alternative Names

5'-N-Ethylcarboxamidoadenosine
View all Non-selective Adenosine Receptor Agonists »

Product Description

NECA is a high affinity adenosine receptor agonist (Ki values are 6.2, 14, and 20 nM for human A3, A1 and A2A receptors respectively; EC50 = 2.4 μM for human A2B). Inhibits platelet aggregation and is centrally active in vivo.

Product Specifications for NECA

Molecular Weight

308.30

Formula

C12H16N6O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide

CAS Number

35920-39-9

PubChem ID

448222

InChI Key

JADDQZYHOWSFJD-FLNNQWSLSA-N

SMILES

O[C@@H]1[C@@H]([C@](NCC)=O)O[C@@H](N2C=NC3=C2N=CN=C3N)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.33 40

Preparing Stock Solutions for NECA

The following data is based on the product molecular weight 308.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.4 mM 8.11 mL 40.54 mL 81.09 mL
2 mM 1.62 mL 8.11 mL 16.22 mL
4 mM 0.81 mL 4.05 mL 8.11 mL
20 mM 0.16 mL 0.81 mL 1.62 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 145 publications citing the usage of this product.

Product Documents for NECA

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NECA

For research use only

Customer Reviews for NECA (2)

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  • Treatment of HEK-A2AR cell
    Name: Tahmineh Safaie
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 02/22/2021
    HEK-A2AR cell lines (BPSBioscience) were treated with Forskolin, NECA, and CGS for 30 minutes and level of cAMP was measured.
    NECA 1691
  • Highly stable
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: brain
    Verified Customer | Posted 05/09/2020
    0.08 mg/kg of NECA
    NECA 1691

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