Ned K

Key Product Details

Product Description

Ned K is a NAADP inhibitor. Prevents Ca²⁺ oscillations in rat cardiomyocytes in vitro during simulated ischemia and reperfusion, but exhibits no significant effect on Ca²⁺ sparks. Significantly reduces infarct size in rat cardiac ischemia/reperfusion model in vivo.

Product Specifications for Ned K

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ned K

The following data is based on the product molecular weight 521.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.83 mL	19.17 mL	38.34 mL
2.5 mM	0.77 mL	3.83 mL	7.67 mL
5 mM	0.38 mL	1.92 mL	3.83 mL
25 mM	0.08 mL	0.38 mL	0.77 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Davidson Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore. Cardiovasc.Res. 2015 PMID:  26395965

Product Documents for Ned K