NESS 0327

Tocris Bioscience | Catalog # 5746

Ultra-high affinity and selective CB1 antagonist
Tocris Bioscience

Key Product Details

Description

Ultra-high affinity and selective CB1 antagonist
View all Cannabinoid R1/CB1 Antagonists »

Product Description

NESS 0327 is an ultra-high affinity and selective CB1 receptor antagonist (Ki = 350 fM). Exhibits >60-fold selectivity for CB1 over CB2 receptors. Antagonizes the inhibitory effects of WIN 55,212-2 (Cat. No. 1038) on electrically evoked contractions in mouse isolated vas deferens ex vivo. Also antagonizes the antinociceptive effect of WIN 55,212-2 in tail-flick and hot plate tests in vivo.

Product Specifications for NESS 0327

Molecular Weight

489.82

Formula

C24H23Cl3N4O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

8-Chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydro-N-1-piperidinyl-benzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide

CAS Number

494844-07-4

PubChem ID

10435654

InChI Key

NCXBPZJQQSNIRA-UHFFFAOYSA-N

SMILES

O=C(NN1CCCCC1)C2=NN(C3=CC=C(Cl)C=C3Cl)C4=C2CCCC5=C4C=CC(Cl)=C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.8 20

Preparing Stock Solutions for NESS 0327

The following data is based on the product molecular weight 489.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.21 mL 51.04 mL 102.08 mL
1 mM 2.04 mL 10.21 mL 20.42 mL
2 mM 1.02 mL 5.10 mL 10.21 mL
10 mM 0.20 mL 1.02 mL 2.04 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for NESS 0327

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NESS 0327

For research use only

Related Research Areas

Bioactive Lipids and Receptors

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