NI 42

Key Product Details

Product Description

NI 42 is a high affinity BRPF inhibitor (K_d values are 40, 210 and 943 nM for BRPF1B, 2 and 3, respectively). Also exhibits modest activity at BRD9 (K_d = 1130 nM). Exhibits selectivity for BRPF over 44 other bromodomains. Orally bioavailable.

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. NI 42 is listed on the Chemical Probes website.

Product Specifications for NI 42

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NI 42

The following data is based on the product molecular weight 353.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.66 mL	28.30 mL	56.59 mL
2.5 mM	1.13 mL	5.66 mL	11.32 mL
5 mM	0.57 mL	2.83 mL	5.66 mL
25 mM	0.11 mL	0.57 mL	1.13 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Igoe Design of a biased potent small molecule inhibitor of the bromodomain and PHD finger-containing (BRPF) proteins suitable for cellular and in vivo studies. J.Med.Chem 2017 PMID: 28068087

Product Documents for NI 42