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NI 42

Catalog #: 5786 Datasheet / COA / SDS

Discontinued Product

5786 has been discontinued.
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NI 42 | CAS No. 1884640-99-6 | Bromodomain Inhibitors
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Description: High affinity BRPF inhibitor

Chemical Name: 4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide

Purity: ≥98%

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Biological Activity

NI 42 is a high affinity BRPF inhibitor (Kd values are 40, 210 and 943 nM for BRPF1B, 2 and 3, respectively). Also exhibits modest activity at BRD9 (Kd = 1130 nM). Exhibits selectivity for BRPF over 44 other bromodomains. Orally bioavailable.
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. NI 42 is listed on the Chemical Probes website.

Technical Data

M.Wt:
353.39
Formula:
C18H15N3O3S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1884640-99-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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