NIBR LTSi

Key Product Details

Product Description

NIBR-LTSi is a potent and selective large tumor suppressor kinase (LATS) inhibitor (IC₅₀ = 1.4 nM). Also activates YAP signaling (EC₅₀ = 1.0 - 2.7 μM). Promotes liver organoid formation (EC₅₀ = 0.35 μM), hepatocyte proliferation, ISC expansion, and blocks differentiation. NIBR-LTSi is orally bioavailable and suitable for use in vivo and in vitro.

Product Specifications for NIBR LTSi

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NIBR LTSi

The following data is based on the product molecular weight 308.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.24 mL	16.21 mL	32.43 mL
5 mM	0.65 mL	3.24 mL	6.49 mL
10 mM	0.32 mL	1.62 mL	3.24 mL
50 mM	0.06 mL	0.32 mL	0.65 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Namoto NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo. Cell Stem Cell 2024 PMID: 38579685

Product Documents for NIBR LTSi