Nicorandil

Tocris Bioscience | Catalog # 2147

Kir6 (KATP) channel opener and NO donor
Tocris Bioscience
Discontinued Product
2147 has been discontinued. View all Inward Rectifier Potassium Channel Activators products.

Key Product Details

Description

Kir6 (KATP) channel opener and NO donor
View all Inward Rectifier Potassium Channel Activators »

Product Description

Kir6 (KATP) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing Kir6 channels (EC50 values are 10 and > 500 μM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.

Product Specifications for Nicorandil

Molecular Weight

211.18

Formula

C8H9N3O4

Storage

Desiccate at +4°C

Chemical Name

N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide

CAS Number

65141-46-0

PubChem ID

47528

InChI Key

LBHIOVVIQHSOQN-UHFFFAOYSA-N

SMILES

[O-][N+](=O)OCCNC(=O)C1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 4.22 20

Preparing Stock Solutions for Nicorandil

The following data is based on the product molecular weight 211.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 23.68 mL 118.38 mL 236.76 mL
1 mM 4.74 mL 23.68 mL 47.35 mL
2 mM 2.37 mL 11.84 mL 23.68 mL
10 mM 0.47 mL 2.37 mL 4.74 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

Product Documents for Nicorandil

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Nicorandil

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Nicorandil (1)

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  • Nicorandil was used to study Kca1.1 channels
    Name: Sadequl Islam
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 11/27/2018
    Nicorandil was used to study Kca1.1 channels which are are voltage-gated potassium channels that conduct large amounts of potassium ions (K+) across the cell membrane. To understand neuronal excitability modulated by BK channel opening, Nicorandil was introduced into the cell line.
    Nicorandil 2147

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