Nicotinamide Riboside

Key Product Details

Product Description

Nicotinamide Riboside is an NAD⁺ precursor. It is a substrate for nicotinamide riboside kinases (NRK1/2). Nicotinamide Riboside shows neuroprotective effects in a mouse model of type 2 diabetes and improves mitochondrial function in muscle stem cells in aged mice. The compound also corrects non-alchoholic fatty liver disease phenotype induced by NAD⁺ deficiency or high-fat diet in mice. Orally bioavailable.

Product Specifications for Nicotinamide Riboside

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Nicotinamide Riboside

The following data is based on the product molecular weight 290.70.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.44 mL	17.20 mL	34.40 mL
5 mM	0.69 mL	3.44 mL	6.88 mL
10 mM	0.34 mL	1.72 mL	3.44 mL
50 mM	0.07 mL	0.34 mL	0.69 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Trammell Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice. Sci.Rep. 2016 PMID: 27230286
• Zhou Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing. Br.J.Pharmacol. 2016 PMID: 27174364
• Zhang NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science 2016 PMID: 27127236

Product Documents for Nicotinamide Riboside