Nimodipine

Tocris Bioscience | Catalog # 0600

CaV1.x blocker
Tocris Bioscience

Key Product Details

Description

CaV1.x blocker
View all Cav1.x Channel Blockers »

Product Description

Nimodipine is a L-type Ca2+ channel blocker. Induces autophagy. Nimodipine is modulating pericytes and other inflammation signals like Hypoxia and leukocyte stalling to improve cognitive function in Alzheimer’s disease. Nimodipine reduces pericytes and other inflammation signals like hypoxia and leukocyte stalling and improves cognitive function in Alzheimer's disease model mice.

Product Specifications for Nimodipine

Molecular Weight

418.45

Formula

C21H26N2O7

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methyloxyethyl 1-methylethyl ester

CAS Number

66085-59-4

PubChem ID

4497

InChI Key

UIAGMCDKSXEBJQ-UHFFFAOYSA-N

SMILES

COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(=C1)[N+]([O-])=O)C(=O)OC(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.84 100

Preparing Stock Solutions for Nimodipine

The following data is based on the product molecular weight 418.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.95 mL 23.90 mL
5 mM 0.48 mL 2.39 mL 4.78 mL
10 mM 0.24 mL 1.19 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 215 publications citing the usage of this product.

Product Documents for Nimodipine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Nimodipine

For research use only

⚠ WARNING: This product can expose you to chemicals including Nimodipine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Nimodipine (1)

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  • The pharmacological inhibitors for electrophysiology assay
    Name: Anonymous
    Species: skate
    Verified Customer | Posted 02/28/2020
    The following concentrations we were used:1 μM Bay K, 10 μM nifedipine, 10 μM nimodipine, 300 nM omega -agatoxin, 1 μM omega -conotoxin, 5 μM mibefradil, 1 μM tetrodotoxin, 1 μM charybdotoxin, 100 nM iberiotoxin, 10 μM NS11021.
    Nimodipine 0600

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