NITD 008

Key Product Details

Product Description

NITD 008 is a selective flavivirus inhibitor. Adenosine analog. Inhibits dengue virus (EC₅₀ = 0.64 μM), hepatitis C virus and cellular entry of Zika virus. Reduces increases of cytokines and NS1 and prevents death in dengue-infected mice. Active in vivo. Orally bioavailable.

Product Specifications for NITD 008

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NITD 008

The following data is based on the product molecular weight 290.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	17.23 mL	86.13 mL	172.25 mL
1 mM	3.45 mL	17.23 mL	34.45 mL
2 mM	1.72 mL	8.61 mL	17.23 mL
10 mM	0.34 mL	1.72 mL	3.45 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

• Barrows A screen of FDA-approved drugs for inhibitors of Zika virus infection. Cell.Host.Microbe. 2016 PMID: 27476412
• Yin An adenosine nucleoside inhibitor of dengue virus. Proc.Natl.Acad.Sci.USA. 2009 PMID: 19918064

Product Documents for NITD 008