NK 7-902

Key Product Details

Product Description

NK 7-902 is a potent and selective molecular glue Degrader of NIMA related kinase 7 (NEK7) (DC₅₀ = 0.2 nM; D_max > 95%). It displays selectivity for NEK7 across all proteins quantified in a proteomics analysis of human primary monocytes and induced pluripotent stem cells (iPSc). Fully degrades NEK7 in human primary monocytes. Partially inhibits NLRP3-dependent IL-1β production. In mice, NK 7-902 induces degradation of NEK7 (30x higher DC₅₀ ) relative to human primary cells. Orally bioavailable.

Product Specifications for NK 7-902

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NK 7-902

The following data is based on the product molecular weight 410.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.44 mL	12.18 mL	24.36 mL
5 mM	0.49 mL	2.44 mL	4.87 mL
10 mM	0.24 mL	1.22 mL	2.44 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Sylvain A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner. Cell Chem.Biol.

Product Documents for NK 7-902