NMS 873

Tocris Bioscience | Catalog # 6180

Potent and selective p97 ATPase (VCP) allosteric inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective p97 ATPase (VCP) allosteric inhibitor
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Product Description

NMS 873 is a potent p97 ATPase (VCP) allosteric inhibitor (IC50 = 30 nM). Selective over all other AAA ATPases, HSP90 and kinases tested (IC50 >10 μM). Activates the unfolded protein response (UPR) and modulates autophagosome maturation. Exhibits antiproliferative activity in cancer cells in vitro (IC50 values are 400 and 700 nM for HCT116 and HeLa cells respectively). Reduces p97-sensitization to trypsin digestion.

Product Specifications for NMS 873

Molecular Weight

520.67

Formula

C27H28N4O3S2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine

CAS Number

1418013-75-8

PubChem ID

71521142

InChI Key

UJGTUKMAJVCBIS-UHFFFAOYSA-N

SMILES

CC1=C(C2=CC=C(S(C)(=O)=O)C=C2)C=CC(OCC3=NN=C(N3C4=CN=CC=C4)SC5CCCC5)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.07 100

Preparing Stock Solutions for NMS 873

The following data is based on the product molecular weight 520.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.92 mL 9.60 mL 19.21 mL
5 mM 0.38 mL 1.92 mL 3.84 mL
10 mM 0.19 mL 0.96 mL 1.92 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

Product Documents for NMS 873

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NMS 873

For research use only

Customer Reviews for NMS 873 (1)

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  • NMS on Dictyostelium mTORC1
    Name: Judith Schaf
    Species: Dictyostelium
    Assay Type: In Vitro
    Verified Customer | Posted 05/23/2019
    Used NMS at 30 nM and 300 nM in Dictyostelium, treated for 1 hour or 24 hours. Then mTORC1 activity was monitored using a western blot for p-4E-BP1. No significant change in p-4E-BP1 levels was observed
    NMS 873 6180

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