NNC 63-0532

Key Product Details

Product Description

NNC 63-0532 is a potent non-peptide agonist for the NOP receptor (EC₅₀ = 305 nM, K_i = 7.3 nM); ~ 12-fold selective over other receptors. Centrally active following systemic administration in vivo.

Product Specifications for NNC 63-0532

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NNC 63-0532

The following data is based on the product molecular weight 443.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.51 mL	22.55 mL	45.09 mL
2.5 mM	0.90 mL	4.51 mL	9.02 mL
5 mM	0.45 mL	2.25 mL	4.51 mL
25 mM	0.09 mL	0.45 mL	0.90 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Thomsen and Hohlweg (8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]-dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist. Br.J.Pharmacol. 2000 PMID: 11053209

Product Documents for NNC 63-0532