Nociceptin

Name: Nociceptin
Brand: Tocris Bioscience
SKU: 0910
Price: 215 USD
Availability: InStock

Tocris Bioscience | Catalog # 0910

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Citations (69)

Product Documents

Endogenous NOP agonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Endogenous NOP agonist

Alternative Names

Orphanin FQ

View all NOP Receptor Agonists »

Product Description

Nociceptin is an endogenous ligand for the NOP opioid receptor (pK_i = 8.6). Has no significant activity at μ, δ or κ opioid receptors (pK_i < 6).

Product Specifications for Nociceptin

Molecular Weight

1809.00

Formula

C₇₉H₁₂₉N₂₇O₂₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

170713-75-4

PubChem ID

16131448

InChI Key

PULGYDLMFSFVBL-SMFNREODSA-N

SMILES

[H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

音量

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Concentration 1 (C1)

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Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

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Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 69 publications citing the usage of this product.

Meunier Isolation and structure of the endogenous agonist of opioid receptor-like ORL₁ receptor. Nature 1995 PMID: 7566152
Henderson and McKnight The orphan opioid receptor and its endogenous ligand-nociceptin/orphanin FQ. TiPS 1997 PMID: 9277133
Reinscheid Orphanin FQ: a neuropeptide that activates an opioid like G protein coupled receptor. Science 1995 PMID: 7481766
Guerrini Structure-activity relationships of nociceptin and related peptides: comparison with dynorphin A. Peptides 2000 PMID: 10998526

Product Documents for Nociceptin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Nociceptin

For research use only

Related Research Areas

Neurotransmitter G Protein-Coupled Receptors

Citations for Nociceptin

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