Nor NOHA monoacetate

Key Product Details

Product Description

Nor NOHA monoacetate is a reversible, competitive arginase inhibitor (IC₅₀ = 2 μM). Exhibits 10-fold selectivity for human type II arginase over type I. Enhances the effect of acetylcholine on isolated aortic and mesenteric arterial rings. Inhibits growth of lung carcinoma implants in mice.

Product Specifications for Nor NOHA monoacetate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Nor NOHA monoacetate

The following data is based on the product molecular weight 236.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.23 mL	21.17 mL	42.33 mL
5 mM	0.85 mL	4.23 mL	8.47 mL
10 mM	0.42 mL	2.12 mL	4.23 mL
50 mM	0.08 mL	0.42 mL	0.85 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Rodriguez Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res. 2004 PMID: 15313928
• Colleluori and Ash Classical and slow-binding inhibitors of human type II arginase. Biochemistry 2001 PMID: 11478904
• Huynh The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries. Br.J.Pharmacol. 2009 PMID: 19133993
• Custot The new α-amino acid N^ω-hydroxy-nor-L-arginine: a high affinity inhibitor of arginase well adapted to bind to its manganese cluster. J.Am.Chem.Soc.

Product Documents for Nor NOHA monoacetate