NPS 2390

Tocris Bioscience | Catalog # 4134

Group I mGlu antagonist
Tocris Bioscience

Key Product Details

Description

Group I mGlu antagonist
View all Group I mGluR Antagonists »

Product Description

NPS 2390 is a group I mGlu antagonist; displays noncompetitive antagonist activity at both mGlu1 and mGlu5 receptors. Thought to act on a site separate from the glutamate binding pocket.

Product Specifications for NPS 2390

Molecular Weight

307.39

Formula

C19H21N3O

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide

CAS Number

226878-01-9

PubChem ID

7067728

InChI Key

ZKFVOZCCAXQXBU-UHFFFAOYSA-N

SMILES

O=C(C4=NC(C=CC=C5)=C5N=C4)NC1(CC3C2)CC(C3)CC2C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.37 50
Ethanol 15.37 50

Preparing Stock Solutions for NPS 2390

The following data is based on the product molecular weight 307.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.51 mL 32.53 mL 65.06 mL
2.5 mM 1.30 mL 6.51 mL 13.01 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
25 mM 0.13 mL 0.65 mL 1.30 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

Product Documents for NPS 2390

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NPS 2390

For research use only

Customer Reviews for NPS 2390 (1)

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  • Use of NPS 2390 to isolate GABA-A receptor response
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Cerebellum
    Verified Customer | Posted 09/17/2019
    Compound requires sonication to be dissolved.
    NPS 2390 was used as a specific blocker of mGluR1 and mGluR5, to isolate pharmacologically response of GABA-A receptors. 10 microM of NPS 2390 in perfusion solution generated a full block of mGluR group I receptor activity, thus leaving a clear GABA-ergic response. Figure: single-channel openings of GABA-A receptor after application of NPS 2390.
    NPS 2390 4134

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