NU 7026

Tocris Bioscience | Catalog # 2828

Selective DNA-PK inhibitor
Tocris Bioscience
Discontinued Product
2828 has been discontinued. View all DNA-dependent Protein Kinase Inhibitors products.

Key Product Details

Description

Selective DNA-PK inhibitor
View all DNA-dependent Protein Kinase Inhibitors »

Product Description

NU 7026 is an ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC50 values are 0.23, 13.0, > 100 and > 100 μM for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.

Product Specifications for NU 7026

Molecular Weight

281.31

Formula

C17H15NO3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one

CAS Number

154447-35-5

PubChem ID

9860529

InChI Key

KKTZALUTXUZPSN-UHFFFAOYSA-N

SMILES

O=C2C1=CC=C3C(C=CC=C3)=C1OC(N4CCOCC4)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.81 10

Preparing Stock Solutions for NU 7026

The following data is based on the product molecular weight 281.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.55 mL 177.74 mL 355.48 mL
0.5 mM 7.11 mL 35.55 mL 71.10 mL
1 mM 3.55 mL 17.77 mL 35.55 mL
5 mM 0.71 mL 3.55 mL 7.11 mL

Calculators

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Product Documents for NU 7026

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NU 7026

For research use only

Related Research Areas

DNA Repair

Customer Reviews for NU 7026 (1)

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  • DNAPKi
    Name: Isabelle Cristine da Costa
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: U2OS
    Verified Customer | Posted 09/23/2021
    I used the DNA-PK inhibitor (NU7026) to treat human osteosarcoma cells (U2OS) and assessed if the inhibition worked by blotting for pDNA-PKcs (S2056). The inhibitor works extremely well!
    NU 7026 2828

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