NVS PAK1 1
Chemical Name: (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide
Biological ActivityNVS PAK1 1 is a potent and selective PAK1 inhibitor (IC50 = 5 nM) that displays selective for PAK1 over PAK2 and a panel of 442 kinases. NVS PAK1 1 inhibits autophosphorylation of PAK1 in KRAS-mutated pancreatic cancer cell lines.
A negative control for NVS PAK1 1 is also available; NVS PAK1 C.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of NVS-PAK1-1 is reviewed on the chemical probes website.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Optimization of a dibenzodiazepine hit to a potent and selective allosteric PAK1 inhibitor.
Karpov et al.
ACS Med.Chem.Lett, 2015;6:776
Citation for NVS PAK1 1
The citations listed below are publications that use Tocris products. Selected citations for NVS PAK1 1 include:
1 Citation: Showing 1 - 1
PAK1 Positively Regulates Oligodendrocyte Morphology and Myelination.
Authors: Teresa L Et al.
J Neurosci 2021;41:1864-1877
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Tocris Small Molecules
Reviews for NVS PAK1 1
There are currently no reviews for this product. Be the first to review NVS PAK1 1 and earn rewards!
Have you used NVS PAK1 1?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image