NVS-ZP7-4

Key Product Details

Product Description

NVS-ZP7-4 is an inhibitor of the zinc transporter ZIP7 (SLC39A7). Inhibition of ZIP7 in T-ALL cell lines increases ER zinc levels and inhibits Notch signalling, inducing apoptosis. Inhibits ferroptosis in cancer cells when used at a concentration of 10 μM.

Product Specifications for NVS-ZP7-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NVS-ZP7-4

The following data is based on the product molecular weight 501.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.99 mL	9.97 mL	19.94 mL
5 mM	0.40 mL	1.99 mL	3.99 mL
10 mM	0.20 mL	1.00 mL	1.99 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Chen Zinc transporter ZIP7 is a novel determinant of ferroptosis. Cell Death Dis. 2021 PMID: 33608508
• Pagliaro Targeting Notch trafficking and processing in cancers. Cells 2020 PMID: 33003595
• Nolin Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat.Chem.Biol. 2019 PMID: 30643281

Product Documents for NVS-ZP7-4