O-1602

Tocris Bioscience | Catalog # 2797

Potent GPR55 agonist
Tocris Bioscience

Key Product Details

Description

Potent GPR55 agonist
View all GPR55 Receptor Agonists »

Product Description

O-1602 is an analog of cannabidiol that is a potent agonist at the GPR55 cannabinoid receptor (EC50 values are 13, > 30000 and > 30000 nM for GPR55, CB1 and CB2 receptors respectively). Induces activation of RhoA, cdc42 and rac1. Increases proliferation of neural stem cells NSCs in vitro and in vivo. Also promotes neurogenesis in vivo.

Product Specifications for O-1602

Molecular Weight

258.36

Formula

C17H22O2

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

5-Methyl-4-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-1,3-benzenediol

CAS Number

317321-41-8

PubChem ID

45073499

InChI Key

KDZOUSULXZNDJH-LSDHHAIUSA-N

SMILES

C=[C@](C)[C@@H]1CCC(C)=C[C@H]1[C@]2=C(O)C=C(O)C=C2C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 41 publications citing the usage of this product.

Product Documents for O-1602

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for O-1602

For research use only

Customer Reviews for O-1602 (2)

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  • breast cancer cell viability by a cannabinoid receptor 2 agonist
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: MCF-7
    Verified Customer | Posted 03/15/2020
    We used all these compounds which were dissolved in DMSO and added to fresh culture media. Concentration reference paper PMID: 27186076
    O-1602 2797
  • O-1602 regulates PGE2 release
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    Verified Customer | Posted 09/21/2019
    When supplier's aliquot is added to work solution, product must be obviously sonicated for proper mixture.
    O-1602 was used to study impact of GPR-55 on prostaglandin E2 release from hippocampal microglial cells. We found that O-1602 causes a clear, albeit not very mighty effect decreasing PGE2 release; concentrations higher than 50 microM did not display a significant difference from effect generated by 50 microM of O-1602.
    O-1602 2797

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