Olanzapine

Key Product Details

Product Description

Olanzapine is an antagonist of 5-HT_2A and dopamine D₂ receptors (K_i values are 4 and 11 nM respectively). Also displays affinity for a range of other receptors including D₁ and D₄, 5-HT_2C, α₁, H₁ and M_1-4 receptors (K_i values range between 1.9 and 31 nM). Atypical antipsychotic. Displays anticholinergic properties. Also a highly potent activator of hM₄D_i DREADDs (EC₅₀ values are 5 nM in vitro and 7 nM in vivo).

Product Specifications for Olanzapine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Olanzapine

The following data is based on the product molecular weight 312.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.20 mL	16.00 mL	32.01 mL
5 mM	0.64 mL	3.20 mL	6.40 mL
10 mM	0.32 mL	1.60 mL	3.20 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

• Moore The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent. J.Pharmacol.Exp.Ther. 1992 PMID: 1354253
• Bymaster Radioreceptor binding profile of the atypical antipsychotic olanz. Neuropsychopharmacology 1996 PMID: 8822531
• Tollefson and Taylor Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent. CNS Drug Reviews

Product Documents for Olanzapine