Olaparib

Tocris Bioscience | Catalog # 7579

Potent PARP inhibitor
Tocris Bioscience

Key Product Details

Description

Potent PARP inhibitor
View all Poly(ADP-ribose) Polymerase Inhibitors »

Product Description

Olaparib is a potent PARP2 and PARP1 inhibitor (IC50 values are 1 and 5 nM, respectively). Olaparib abolishes PARP-1 activity at a concentration of 30-100 nM in SW620 cell lysates. BRCA1-deficient cell lines are hypersensitive to PARP inhibition by Olaparib in comparison with BRCA1- and BRCA2-proficient cells. Olaparib potentiates the antitumor activity of the methylating chemotherapeutic agent Temozolomide (Cat. No. 2706) in xenograft mouse model. Olaparib is orally bioavailable in rats.

Product Specifications for Olaparib

Molecular Weight

434.47

Formula

C24H23FN4O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone

CAS Number

763113-22-0

PubChem ID

23725625

InChI Key

FDLYAMZZIXQODN-UHFFFAOYSA-N

SMILES

O=C1NN=C(C=2C=CC=CC12)CC3=CC=C(F)C(=C3)C(=O)N4CCN(C(=O)C5CC5)CC4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.45 100
Ethanol 2.17 5 with gentle warming

Preparing Stock Solutions for Olaparib

The following data is based on the product molecular weight 434.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.30 mL 11.51 mL 23.02 mL
5 mM 0.46 mL 2.30 mL 4.60 mL
10 mM 0.23 mL 1.15 mL 2.30 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 20 publications citing the usage of this product.

Product Documents for Olaparib

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Olaparib

For research use only

Related Research Areas

Apoptosis

Customer Reviews for Olaparib (1)

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  • PARP inhibitor
    Name: Kishor Pant
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: RBE and HepG2
    Verified Customer | Posted 11/30/2022
    It's an excellent selective inhibitor of PARP. This drug induces DNA damage in cancer cells. Used at 1-10 uM.
    Olaparib 7579

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