Omeprazole

Tocris Bioscience | Catalog # 2583

H+,K+-ATPase inhibitor
Tocris Bioscience
Discontinued Product
2583 has been discontinued. View all H+/K+ ATPase Inhibitors products.

Key Product Details

Description

H+,K+-ATPase inhibitor
View all H+/K+ ATPase Inhibitors »

Product Description

Omeprazole is a H+,K+-ATPase inhibitor (IC50 = 5.8 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC50 = 0.16 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro. Also inhibits CYP2C19, CYP2C9 and CYP3A (Ki values are 3.1, 40.1 and 84.4 μM respectively) and blocks swelling-dependent chloride channels (ICIswell). Enhances anti-SARS-CoV-2 acitvity of Remdesivir and Aprotinin (Cat. No. 4139).

Product Specifications for Omeprazole

Molecular Weight

345.42

Formula

C17H19N3O3S

Storage

Desiccate at +4°C

Purity

≥99% (HPLC)

Chemical Name

5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole

CAS Number

73590-58-6

PubChem ID

4594

InChI Key

SUBDBMMJDZJVOS-UHFFFAOYSA-N

SMILES

COC1=CC=C2N=C(NC2=C1)S(=O)CC1=C(C)C(OC)=C(C)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 17.27 50
DMSO 34.54 100

Preparing Stock Solutions for Omeprazole

The following data is based on the product molecular weight 345.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.90 mL 14.48 mL 28.95 mL
5 mM 0.58 mL 2.90 mL 5.79 mL
10 mM 0.29 mL 1.45 mL 2.90 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Omeprazole

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Omeprazole

For research use only

Customer Reviews for Omeprazole (1)

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  • Enzimes in the Lab
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: blood
    Verified Customer | Posted 01/04/2018
    We prepare the solutions the same day of use
    We use it in the pharmacology lab for the assigment experiments

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