Opicapone

Key Product Details

Product Description

Opicapone is a reversible catechol O-methyltransferase inhibitor (COMT) inhibitor (IC₅₀ = 224 nM). Decreases the ATP content and mitochondrial membrane potential in cells (IC₅₀ values are 98 μM and 181 μM respectively). When administered with L-DOPA (Cat. No. 3788) it attenuates Parkinson's-like symptoms in an MPTP-induced animal model.

Product Specifications for Opicapone

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Opicapone

The following data is based on the product molecular weight 413.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.42 mL	12.10 mL	24.20 mL
5 mM	0.48 mL	2.42 mL	4.84 mL
10 mM	0.24 mL	1.21 mL	2.42 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Bonifácio Opicapone enhances the reversal of MPTP-induced Parkinson-like syndrome by levodopa in cynomolgus monkeys. Eur.J.Pharmacol. 2021 PMID: 33220276
• Ettcheto The preclinical discovery and development of opicapone for the treatment of Parkinson's disease. Expert Opin.Drug Discov. 2020 PMID: 32450711

Product Documents for Opicapone